Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis
of multiple sclerosis. The use of imaging for demonstration of dissemination of central …

The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research
and clinical practice. Scientific advances in the past 7 years suggest that they might no …

Importance It remains unclear whether vitamin D insufficiency, which is common in
individuals with multiple sclerosis (MS), has an adverse effect on MS outcomes. Objectives To …

Natural history studies have identified factors that predict evolution to multiple sclerosis or risk
of disability accumulation over time. Although these studies are based on large multicentre …

Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

In patients presenting with a clinically isolated syndrome, MRI can support and substitute
clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in …

Background and purpose Information regarding multiple sclerosis (MS) patients with the 2019
novel coronavirus disease (COVID‐19) is scarce. The study objective was to describe the …

Background Bruton’s tyrosine kinase (BTK) regulates the functions of B cells and myeloid cells
that are implicated in the pathogenesis of multiple sclerosis. Evobrutinib is a selective oral …

Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important
for communication, prognostication, design and recruitment of clinical trials, and treatment …