Background Enzyme replacement therapy (ERT) slows disease progression of Fabry disease
(FD), especially when initiated before the onset of irreversible organ damage. However, …

Quality of life (QoL) is decreased in patients with Fabry disease (FD). To improve QoL, it is
important to understand the influence of FD related characteristics, symptoms, and …

Background Fabry disease (FD) is a rare lysosomal storage disorder that might result in,
amongst other complications, early stroke and white matter lesions (WMLs). More insight in …

Background Despite the high prevalence of depressive symptoms in Fabry disease (FD), it
is unclear which patient characteristics are important in relation to these symptoms. …

Background and aim It is unclear which patients with Fabry disease (FD) are at risk for
progression of white matter lesions (WMLs) and brain infarctions and whether enzyme …

This study investigates the relationship between objective cognitive impairment (OCI),
subjective cognitive complaints and depressive symptoms in men and women with classical and …

Highlights • The development process of enzyme replacement therapy (ERT) was subject to
pitfalls. • Evidence for real-world effectiveness of ERT for Fabry disease (FD) is disappointing…

BACKGROUND AND PURPOSE: White matter lesions are commonly found in patients with
Fabry disease. Existing studies have shown elevated diffusivity in healthy-appearing brain …

Patients with Fabry disease (FD) have a high prevalence of depressive symptoms and can
suffer from cognitive impairment, negatively affecting their life. The course of cognitive …

Fabry disease (FD) patients may suffer from objective cognitive impairment (OCI). This study
assessed the accuracy of the Mini Mental State Examination (MMSE) to screen for OCI in …